The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?

Abstract

INTRODUCTION:

The etiology and pathogenesis of osteoarthritis (OA) have been intensely investigated; however, the disease course and progression are not completely understood. A prominent role for interstitial collagenases is recognized in this degenerative process; hence, strategies to target them are of major interest.

AREAS COVERED:

The pathogenesis of OA, the role of interstitial collagenases (MMP-1, -8, and -13), and collagenase modifying drugs are examined and discussed. We reviewed relevant papers from PubMed and Google Scholar.

EXPERT OPINION:

There is strong evidence for the therapeutic potential of MMP inhibitors in OA; however, they are not expected to impact the inflammatory process. Therefore, there is a need for a relative inhibitor of MMP-13 collagenase, which possesses anti-inflammatory properties. The identification of novel broad-spectrum relative to multiple peptidase inhibitors could provide desirable tools for the prophylaxis, cure, or treatment of diseases involving articular cartilage (AC) degradation, in particular OA.

• Authors: Tuomo Karila, Taina Tervahartiala, Beniamin Cohen, Timo Sorsa
• Journal: Expert opinion on therapeutic targets (Expert Opin Ther Targets) Vol. 26 Issue 2 Pg. 93-105 (02 2022) ISSN: 1744-7631 [Electronic] England
• PMID: 35081858 (Publication Type: Journal Article)

Chemical References

• Collagenases

Topics

• Cartilage, Articular (metabolism, pathology)
• Collagenases (metabolism)
• Humans
• Osteoarthritis (drug therapy)