EOGT Correlated With Immune Infiltration: A Candidate Prognostic Biomarker for Hepatocellular Carcinoma.
Abstract | Background: Methods: Initially, EOGT expression was evaluated by Oncomine, TIMER, GEO, and UALCAN databases. Besides, the prognostic potential of EOGT expression was analyzed using GEPIA, Kaplan-Meier plotter, CPTAC, Cox regression, and nomogram in HCC samples. Furthermore, we investigated the association between EOGT expression and tumor mutation burden, DNA methylation, and immune infiltration in addition to its possible mechanism via cBioPortal, TIMER, GEPIA, ESTIMATE, CIBERSORT, GSEA, STRING, and Cytoscape. Results: The expression of EOGT in HCC was significantly higher than that in normal tissues. Additionally, elevated EOGT expression was correlated with advanced tumor staging and linked to poor overall survival and relapse-free survival, serving as a significant unfavorable prognostic indicator in HCC patients. Remarkably, our results revealed that high-EOGT expression subgroups with elevated TP53 or low CTNNB1 mutations have worse clinical outcomes than the others. Regarding immune infiltration, immunofluorescent staining showed that immune cells in HCC were positive for EOGT. Besides, elevated EOGT expression was linked to exhausted T cells and immune suppressor cells in HCC samples. More importantly, the proportion of CD8+ T cells was reduced in HCC samples with a high level of EOGT expression, but EOGT did not exhibit prognostic potential in HCC samples with increased CD8+ T cells. Conclusions: EOGT may hold great potential as a novel biomarker to distinguish prognosis and immune profiles of HCC patients.
|
Authors | Yang Shu, Lingling He, Meixin Gao, Fan Xiao, Junru Yang, Shiwei Wang, Herui Wei, Fuyang Zhang, Hongshan Wei |
Journal | Frontiers in immunology
(Front Immunol)
Vol. 12
Pg. 780509
( 2021)
ISSN: 1664-3224 [Electronic] Switzerland |
PMID | 35069551
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2022 Shu, He, Gao, Xiao, Yang, Wang, Wei, Zhang and Wei. |
Chemical References |
- Biomarkers, Tumor
- Neoplasm Proteins
- EOGT protein, human
- N-Acetylglucosaminyltransferases
|
Topics |
- Adult
- Biomarkers, Tumor
(immunology)
- CD8-Positive T-Lymphocytes
(immunology)
- Carcinoma, Hepatocellular
(immunology, mortality)
- Disease-Free Survival
- Female
- Humans
- Liver Neoplasms
(immunology, mortality)
- Lymphocytes, Tumor-Infiltrating
(immunology)
- Male
- Middle Aged
- N-Acetylglucosaminyltransferases
(immunology)
- Neoplasm Proteins
(immunology)
- Survival Rate
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|