[Significance of Neoadjuvant Chemotherapy before Colorectomy and Hepatectomy].

Abstract

BACKGROUND:

We discuss the significance of neoadjuvant chemotherapy for resectable simultaneous liver metastases in our department.

SUBJECT:

We examined 73 cases of resectable simultaneous colorectal liver metastases surgeries occurred in our department from 2000 to 2019.

RESULTS:

There were 13 patients in the chemotherapy before colorectomy group(before colorectomy group), 24 patients in the chemotherapy before hepatectomy group(before hepatectomy group), and 36 patients in the no chemotherapy group(no chemo group). Five-year overall survival in Grade A/B was 77.8%/100% in the before colorectomy group, 50.0%/42.4% in the before hepatectomy group and 45.6%/66.2% in the no chemo group. Three-year progression-free survival in Grade A/B was 51.9%/50.0% in the before colorectomy group, 16.7%/40.4% in the before hepatectomy group and 46.5%/55.6% in the no chemo group. Six patients in the before colorectomy group had no local recurrence, lymph node recurrence, or peritoneal dissemination.

CONCLUSION:

Patients in the before colorectomy group were expected to have prolonged survival. There was no local recurrence, lymph node recurrence, or peritoneal dissemination in the before colorectomy group, suggesting the possibility of controlling them.

• Authors: Daisuke Kuwata, Takuya Miura, Yoshiyuki Sakamoto, Hajime Morohashi, Daichi Ichinohe, Hiroaki Fujita, Keisuke Yamazaki, Kenichi Hakamada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 48 Issue 13 Pg. 1541-1543 (Dec 2021) ISSN: 0385-0684 [Print] Japan
• PMID: 35046249 (Publication Type: Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Colorectal Neoplasms (surgery)
• Hepatectomy
• Humans
• Liver Neoplasms (drug therapy, surgery)
• Neoadjuvant Therapy
• Neoplasm Recurrence, Local (surgery)