Effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease and sleep disorder: A randomized controlled trial.

Abstract

OBJECTIVE:

To investigate the effects of eszopiclone on sleep quality and cognitive function in elderly patients with Alzheimer's disease (AD) and sleep disorders.

METHODS:

This study was a prospective study of 96 elderly patients with AD and sleep disturbance treated in our hospital from April 2019 to December 2020. All patients were divided into a control group (48 patients, given alprazolam tablets) and a study group (48 patients, given eszopiclone) according to the random number table method.

RESULTS:

After treatment, compared with the control group, the study group had lower sleep latency, daytime function, sleep disturbance, sleep efficiency, sleep quality, sleeping time, and hypnotic medication scores (p < .05). After treatment, sleep progression and sleep architecture improvement were more obvious in the study group compared with the control group (p < .05). After treatment, compared with the control group, the rhythm disturbance, psychotic disorder, hallucination, phobic anxiety, and disorder in the study group improved more significantly (p < .05). After treatment, compared with the control group, the scores of orientation, attention, memory, calculation, recall, and language ability in the study group improved more significantly (p < .05). After treatment, the scores of the physical life self-care scale and instrumental activities of daily living scale in the study group were improved more obviously compared with the control group, with significant differences (p < .05).

CONCLUSION:

Eszopiclone can effectively improve the quality of sleep and cognitive function in elderly patients with AD and sleep disorder.

• Authors: Shuyu Huo, Lin Cheng, Shuying Li, Fulu Xu
• Journal: Brain and behavior (Brain Behav) Vol. 12 Issue 2 Pg. e2488 (02 2022) ISSN: 2162-3279 [Electronic] United States
• PMID: 35041261 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.

Chemical References

• Hypnotics and Sedatives
• Eszopiclone

Topics

• Activities of Daily Living
• Aged
• Alzheimer Disease (complications, drug therapy)
• Cognition
• Double-Blind Method
• Eszopiclone (therapeutic use)
• Humans
• Hypnotics and Sedatives (pharmacology, therapeutic use)
• Prospective Studies
• Sleep Initiation and Maintenance Disorders
• Sleep Quality
• Sleep Wake Disorders (drug therapy, etiology)
• Treatment Outcome