Abstract | BACKGROUND/PURPOSE: MATERIALS AND METHODS: RESULTS: Common histological features could be found in the primary OSCCs and their cervical lymph node metastatic cancer lesions after chemotherapy. These included direct killing of cancer cells by chemotherapeutic agents, resulting in cancer cell necrosis and degeneration in the early phase, and squamous and keratinizing metaplasia of drug-induced cancer cells, leading to individual cell keratinization and keratin pearl formation in the later phase. There were also small nests of drug-resistant proliferating cancer cells in the inflamed fibrous connective tissue stroma. The most characteristic histological feature in the metastatic lymph nodes after chemotherapy was the keratinizing metaplasia of the metastatic cancer cells, resulting in the formation of epidermoid cyst-like lesions. CONCLUSION:
|
Authors | Feng-Chou Cheng, Ling-Hsia Wang, Yi-Ping Wang, Julia Yu-Fong Chang, Chun-Pin Chiang |
Journal | Journal of dental sciences
(J Dent Sci)
Vol. 17
Issue 1
Pg. 49-56
(Jan 2022)
ISSN: 2213-8862 [Electronic] Netherlands |
PMID | 35028019
(Publication Type: Journal Article)
|
Copyright | © 2021 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. |