Abstract | BACKGROUND: METHODS: In this randomized, double-blind trial, 117 patients with major depressive disorder aged 55 years or older received 8-week treatment of 250-1500 mg/d of sodium benzoate, 25-150 mg/d of sertraline, or placebo in 2 medical centers. The primary outcome measures were Hamilton Depression Rating Scale and Perceived Stress Scale scores. RESULTS: Three treatments similarly decreased clinicians-rated Hamilton Depression Rating Scale scores. Compared with placebo, sodium benzoate but not sertraline substantially improved Perceived Stress Scale scores and cognitive function. Sertraline, but not benzoate, significantly reduced self-report Geriatric Depression Scale scores. Benzoate and placebo showed similar safety profiles, while sertraline was more likely to raise low-density lipoprotein than benzoate and placebo. Benzoate-treated patients were less likely to drop out than sertraline or placebo recipients. CONCLUSIONS:
Sertraline can reduce subjective depressive symptoms, while benzoate can decrease perceived stress, improve cognitive function, and enhance treatment adherence in late-life depression patients. The results show promise for D-amino acid oxidase inhibition as a novel approach for perceived stress and cognitive decline among patients with late-life depression. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03414931. Registered January 2016.
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Authors | Chieh-Hsin Lin, Shi-Heng Wang, Hsien-Yuan Lane |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 25
Issue 7
Pg. 545-555
(08 04 2022)
ISSN: 1469-5111 [Electronic] England |
PMID | 35023557
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2022. Published by Oxford University Press on behalf of CINP. |
Chemical References |
- Receptors, N-Methyl-D-Aspartate
- Serotonin Uptake Inhibitors
- Oxidoreductases
- Sodium Benzoate
- Sertraline
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Topics |
- Aged
- Cognition
- Depressive Disorder, Major
(drug therapy)
- Double-Blind Method
- Humans
- Middle Aged
- Oxidoreductases
(antagonists & inhibitors)
- Psychiatric Status Rating Scales
- Receptors, N-Methyl-D-Aspartate
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Sertraline
(therapeutic use)
- Sodium Benzoate
(therapeutic use)
- Stress, Psychological
- Treatment Outcome
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