Allogeneic platelet-derived growth factors local injection in treatment of tennis elbow: a prospective randomized controlled study.

Abstract

PURPOSE:

The purpose of this study aimed to evaluate the efficacy of local injection of allogeneic platelet-derived growth factors in treatment of patients with tennis elbow.

PATIENTS AND METHODS:

This study included 120 tennis elbow patients randomly divided into two groups. The patients were locally injected with allogeneic growth factors (treatment group) or with normal saline (control group). The outcomes were assessed using Patient-Related Tennis Elbow Evaluation (PRTEE) and quick Disabilities of the Arm, Shoulder and Hand (qDASH) scales. The clinical outcomes were accordingly classified as excellent, good and poor. The patient's satisfaction and adverse effects were also recorded.

RESULTS:

There was no statistically significant difference between the two groups regarding the age, gender, dominant arm or the pre-injection scores. At three month follow-up, the reductions in the mean PRTEE and qDASH scores were 88.7% and 70.6% in the treatment group versus 21.8% and 14.9% in the control group, respectively. At the last follow-up, the outcomes in the treatment group were excellent in 85% of patients and good in 15%, versus 8% and 32% in the control group. Overall, 95% were satisfied in the treatment group compared to 25% in control group. Forty patients in the treatment group experienced mild transient post-injection pain.

CONCLUSION:

This study strongly suggests that local injection of allogeneic platelet-derived growth factors could be a promising safe treatment option for tennis elbow with significant pain relief, functional improvement and patient's satisfaction. Yet, additional larger studies are needed to assess the durability of these outcomes.

• Authors: Mahmoud Ibrahim Kandil, Abdel-Salam Abdel-Aleem Ahmed, Rasha Shaker Eldesouky, Sherif Eltregy
• Journal: International orthopaedics (Int Orthop) Vol. 46 Issue 3 Pg. 581-588 (03 2022) ISSN: 1432-5195 [Electronic] Germany
• PMID: 35020026 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s).

Chemical References

• Platelet-Derived Growth Factor

Topics

• Humans
• Injections
• Platelet-Derived Growth Factor (administration & dosage)
• Prospective Studies
• Tennis Elbow (therapy)
• Treatment Outcome