Abstract | BACKGROUND: METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer. RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and- progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85). CONCLUSION:
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Authors | Merete Ellingjord-Dale, Sofia Christakoudi, Elisabete Weiderpass, Salvatore Panico, Laure Dossus, Anja Olsen, Anne Tjønneland, Rudolf Kaaks, Matthias B Schulze, Giovanna Masala, Inger T Gram, Guri Skeie, Ann H Rosendahl, Malin Sund, Tim Key, Pietro Ferrari, Marc Gunter, Alicia K Heath, Konstantinos K Tsilidis, Elio Riboli, additional authors |
Journal | International journal of epidemiology
(Int J Epidemiol)
Vol. 50
Issue 6
Pg. 1914-1926
(01 06 2022)
ISSN: 1464-3685 [Electronic] England |
PMID | 34999853
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association. |
Topics |
- Adult
- Body Mass Index
- Breast Neoplasms
(epidemiology)
- Female
- Humans
- Middle Aged
- Prospective Studies
- Risk Factors
- Weight Gain
- Young Adult
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