Tofacitinib as a pragmatic treatment choice for alopecia areata: A retrospective review.

Abstract

Alopecia areata (AA) is an immune-mediated hair loss disease for which targeted immune treatments including Janus kinase (JAK) inhibitors, for example, tofacitinib, are emerging. More literature is needed on the safety and efficacy of JAK inhibitors, and treatment has the potential to be cost prohibitive. This study was conducted to measure safety and efficacy outcomes of off-label use of tofacitinib in AA. A secondary outcome was analysis of payment methods. We reviewed 35 AA patients treated with tofacitinib in a specialty hair disease clinic between January 2013 and July 2019 for outcomes, adverse events, and feasibility of treatment. No serious adverse events were experienced. 83.9% of patients experienced clinically significant scalp regrowth, and 32.3% experienced near total/total regrowth. Though this study was confined to retrospective analysis, the results showed that tofacitinib was safe, effective, and practical for this cohort of 35 AA patients.

• Authors: Sarah Benton, Ronda Farah, Rebecca Freese, Maria Hordinsky
• Journal: Dermatologic therapy (Dermatol Ther) Vol. 35 Issue 4 Pg. e15310 (04 2022) ISSN: 1529-8019 [Electronic] United States
• PMID: 34997820 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley Periodicals LLC.

Chemical References

• Piperidines
• Pyrimidines
• Pyrroles
• tofacitinib

Topics

• Alopecia (chemically induced)
• Alopecia Areata (chemically induced, drug therapy)
• Humans
• Piperidines
• Pyrimidines (adverse effects)
• Pyrroles (adverse effects)
• Retrospective Studies