Coffee Intake of Colorectal Cancer Patients and Prognosis According to Histopathologic Lymphocytic Reaction and T-Cell Infiltrates.

Abstract

Given previous biologic evidence of immunomodulatory effects of coffee, we hypothesized that the association between coffee intake of colorectal cancer patients and survival differs by immune responses. Using a molecular pathologic epidemiology database of 4465 incident colorectal cancer cases, including 1262 cases with molecular data, in the Nurses' Health Study and the Health Professionals Follow-up Study, we examined the association between coffee intake of colorectal cancer patients and survival in strata of levels of histopathologic lymphocytic reaction and T-cell infiltrates in tumor tissue. We did not observe a significant association of coffee intake with colorectal cancer-specific mortality (multivariable-adjusted hazard ratio [HR] for 1-cup increase of coffee intake per day, 0.93; 95% CI, 0.84 to 1.03). Although statistical significance was not reached at the stringent level (α=.005), the association of coffee intake with colorectal cancer-specific mortality differed by Crohn disease-like lymphoid reaction (Pinteraction=.007). Coffee intake was associated with lower colorectal cancer-specific mortality in patients with high Crohn disease-like reaction (multivariable HR for 1-cup increase of coffee intake per day, 0.55; 95% CI, 0.37 to 0.81; Ptrend=.002) but not in patients with intermediate Crohn disease-like reaction (the corresponding HR, 1.02; 95% CI, 0.72 to 1.44) or negative/low Crohn disease-like reaction (the corresponding HR, 0.95; 95% CI, 0.83 to 1.07). The associations of coffee intake with colorectal cancer-specific mortality did not significantly differ by levels of other lymphocytic reaction or any T-cell subset (Pinteraction>.18). There is suggestive evidence for differential prognostic effects of coffee intake by Crohn disease-like lymphoid reaction in colorectal cancer.

• Authors: Tomotaka Ugai, Koichiro Haruki, Juha P Väyrynen, Jennifer Borowsky, Kenji Fujiyoshi, Mai Chan Lau, Naohiko Akimoto, Rong Zhong, Junko Kishikawa, Kota Arima, Shan-Shan Shi, Melissa Zhao, Charles S Fuchs, Xuehong Zhang, Marios Giannakis, Mingyang Song, Hongmei Nan, Jeffrey A Meyerhardt, Molin Wang, Jonathan A Nowak, Shuji Ogino
• Journal: Mayo Clinic proceedings (Mayo Clin Proc) Vol. 97 Issue 1 Pg. 124-133 (01 2022) ISSN: 1942-5546 [Electronic] England
• PMID: 34996545 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Chemical References

• Coffee

Topics

• Aged
• Coffee
• Colorectal Neoplasms (mortality, pathology)
• Female
• Humans
• Male
• Middle Aged
• Proportional Hazards Models
• Retrospective Studies
• T-Lymphocytes (metabolism)