[Advances in the structure and physiological function of protein kinase CK2].

Abstract

Protein kinase CK2 is a common, evolutionarily conserved and ubiquitous protein kinase. In recent years, increasing evidences have shown that CK2 has a variety of phosphorylated protein substrates, which play important roles in growth, development and various diseases. Therefore, CK2 may participate in these physiological processes by regulating the phosphorylation of these substrates. This article briefly reviewed the structural characteristics of protein kinase CK2 and its physiological functions in growth, development, immunity, formation of tumor and other diseases, in order to provide knowledge basis for further research on the regulatory mechanism of CK2 and potential applications of its inhibitors.

• Authors: Chenchen Wan, Yuanli Chen, Tingting Fan
• Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology (Sheng Wu Gong Cheng Xue Bao) Vol. 37 Issue 12 Pg. 4201-4214 (Dec 25 2021) ISSN: 1872-2075 [Electronic] China
• PMID: 34984868 (Publication Type: Journal Article, Review)

Chemical References

• Proteins
• Casein Kinase II

Topics

• Casein Kinase II (genetics, metabolism)
• Phosphorylation
• Proteins