Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan.

Abstract

The circulation of avian influenza A viruses in poultry is a public health concern due to the potential transmissibility and severity of these viral infections. Monitoring the susceptibility of these viruses to antivirals is important for developing measures to strengthen the level of preparedness against influenza pandemics. However, drug susceptibility information on these viruses is limited. Here, we determined the susceptibilities of avian influenza A(H5N1), A(H5N2), A(H5N8), A(H7N7), A(H7N9), A(H9N1), and A(H9N2) viruses isolated in Japan to the antivirals approved for use there: an M2 inhibitor (amantadine), neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, and laninamivir) and RNA polymerase inhibitors (baloxavir and favipiravir). Genotypic methods that detect amino acid substitutions associated with antiviral resistance and phenotypic methods that assess phenotypic viral susceptibility to drugs have revealed that these avian influenza A viruses are susceptible to neuraminidase and RNA polymerase inhibitors. These results suggest that neuraminidase and RNA polymerase inhibitors currently approved in Japan could be a treatment option against influenza A virus infections in humans.

• Authors: Emi Takashita, Hiroko Morita, Shiho Nagata, Masayuki Shirakura, Seiichiro Fujisaki, Hideka Miura, Ikuyo Takayama, Tomoko Arita, Yasushi Suzuki, Masaoki Yamaoka, Taichiro Tanikawa, Ryota Tsunekuni, Junki Mine, Saki Sakuma, Yuko Uchida, Akihiro Shibata, Mari Iwanaka, Noriko Kishida, Kazuya Nakamura, Tsutomu Kageyama, Shinji Watanabe, Hideki Hasegawa, Influenza Virus Surveillance Group of Japan
• Journal: Japanese journal of infectious diseases (Jpn J Infect Dis) Vol. 75 Issue 4 Pg. 398-402 (Jul 22 2022) ISSN: 1884-2836 [Electronic] Japan
• PMID: 34980710 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Enzyme Inhibitors
• Oseltamivir
• DNA-Directed RNA Polymerases
• Neuraminidase

Topics

• Animals
• Antiviral Agents (pharmacology, therapeutic use)
• DNA-Directed RNA Polymerases
• Drug Resistance, Viral (genetics)
• Enzyme Inhibitors (pharmacology, therapeutic use)
• Humans
• Influenza A Virus, H5N1 Subtype (drug effects)
• Influenza A Virus, H5N2 Subtype (drug effects)
• Influenza A Virus, H7N7 Subtype (drug effects)
• Influenza A Virus, H7N9 Subtype (drug effects)
• Influenza A Virus, H9N2 Subtype (drug effects)
• Influenza in Birds (epidemiology, virology)
• Influenza, Human (epidemiology, virology)
• Japan (epidemiology)
• Neuraminidase (genetics, metabolism)
• Oseltamivir (pharmacology, therapeutic use)
• Poultry