Fibrocytes: A Critical Review and Practical Guide.

Abstract

Fibrocytes are hematopoietic-derived cells that directly contribute to tissue fibrosis by producing collagen following injury, during disease, and with aging. The lack of a fibrocyte-specific marker has led to the use of multiple strategies for identifying these cells in vivo. This review will detail how past studies were performed, report their findings, and discuss their strengths and limitations. The motivation is to identify opportunities for further investigation and promote the adoption of best practices during future study design.

• Authors: James W Reinhardt, Christopher K Breuer
• Journal: Frontiers in immunology (Front Immunol) Vol. 12 Pg. 784401 ( 2021) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 34975874 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
• Copyright: Copyright © 2021 Reinhardt and Breuer.

Chemical References

• Collagen Type I

Topics

• Animals
• Cells, Cultured
• Collagen Type I (metabolism)
• Disease Models, Animal
• Fibrosis (immunology, pathology)
• Humans
• Mesoderm (cytology)
• Primary Cell Culture
• Stromal Cells (immunology, metabolism)