The Role of miRNA in Ovarian Cancer: an Overview.

Abstract

Ovarian cancer (OC) is a highly malignant disease that seriously threatens women's health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene expressions through RNA degradation and/or translation inhibition. This review summarizes the current studies on miRNAs in OC and introduces the latest updates of miRNAs in the early screening, treatment, and prognostic prediction of OC, thereby demonstrating the clinical significance of miRNAs in OC. Further exploration on potential targets of miRNAs in OC may provide new insights on optimizing the diagnosis and treatment of OC. MiRNAs are important driving factors for the progression of OC and the dysregulation of miRNAs can serve as biomarkers in the diagnosis, treatment and prognosis of OC. Therefore, miRNAs are potential biological targets for early screening, targeted therapy, drug resistance monitoring, and prognosis improvement in malignancies such as OC.

• Authors: Lihui Zhao, Xiaolei Liang, Liyan Wang, Xuehong Zhang
• Journal: Reproductive sciences (Thousand Oaks, Calif.) (Reprod Sci) Vol. 29 Issue 10 Pg. 2760-2767 (10 2022) ISSN: 1933-7205 [Electronic] United States
• PMID: 34973152 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s).

Chemical References

• MicroRNAs

Topics

• Carcinoma, Ovarian Epithelial (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs (metabolism)
• Ovarian Neoplasms (diagnosis, genetics, metabolism)
• Prognosis