Structure-Property-Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia.

Abstract

Magnetite and maghemite multicore nanoflowers (NFs) synthesized using the modified polyol-mediated routes are to date among the most effective nanoheaters in magnetic hyperthermia (MHT). Recently, magnetite NFs have also shown high photothermal (PT) performances in the most desired second near-infrared (NIR-II) biological window, making them attractive in the field of nanoparticle-activated thermal therapies. However, what makes magnetic NFs efficient heating agents in both modalities still remains an open question. In this work, we investigate the role of many parameters of the polyol synthesis on the final NFs' size, shape, chemical composition, number of cores, and crystallinity. These nanofeatures are later correlated to the magnetic, optical, and electronic properties of the NFs as well as their collective macroscopic thermal properties in MHT and PT to find relationships between their structure, properties, and function. We evidence the critical role of iron(III) and heating ramps on the elaboration of well-defined NFs with a high number of multicores. While MHT efficiency is found to be proportional to the average number of magnetic cores within the assemblies, the optical responses of the NFs and their collective photothermal properties depend directly on the mean volume of the NFs (as supported by optical cross sections numerical simulations) and strongly on the structural disorder in the NFs, rather than the stoichiometry. The concentration of defects in the nanostructures, evaluated by photoluminescence and Urbach energy (EU), evidence a switch in the optical behavior for a limit value of EU = 0.4 eV where a discontinuous transition from high to poor PT efficiency is also observed.

• Authors: Enzo Bertuit, Emilia Benassai, Guillaume Mériguet, Jean-Marc Greneche, Benoit Baptiste, Sophie Neveu, Claire Wilhelm, Ali Abou-Hassan
• Journal: ACS nano (ACS Nano) Vol. 16 Issue 1 Pg. 271-284 (Jan 25 2022) ISSN: 1936-086X [Electronic] United States
• PMID: 34963049 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ferric oxide
• Ferric Compounds
• Ferrosoferric Oxide

Topics

• Ferric Compounds (chemistry)
• Ferrosoferric Oxide
• Hyperthermia, Induced
• Magnetic Phenomena