Abstract |
PURPOSE: METHODS: A total of 4,258 postmenopausal women participated in the Japanese Osteoporosis Intervention Trial protocol number 4 (JOINT-04 trial) and number 5 (JOINT-05 trial), which were multi-center, open-label, randomized controlled trials in Japan. Of these, 3,670 non-edentulous subjects participated in the study. Subjects who had self-reported symptoms of periodontal disease at baseline were defined as having periodontal disease. The study outcome was the difference in BMD changes during the study between subjects with and without periodontal disease. Mixed models for repeated measures after adjusting for covariates were used to investigate the difference in the BMD changes during the study between subjects with and without periodontal disease. RESULTS: CONCLUSIONS: The presence of self-reported symptoms of periodontal disease may be associated with a decrease in the effect of osteoporosis medications in Japanese postmenopausal women.
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Authors | Akira Taguchi, Yukari Uemura, Shiro Tanaka, Hiroaki Ohta, Satoshi Mori, Hiroshi Hagino, Masataka Shiraki, Toshitaka Nakamura, Satoshi Soen, Adequate Treatment of Osteoporosis (A-TOP) research group |
Journal | Archives of osteoporosis
(Arch Osteoporos)
Vol. 17
Issue 1
Pg. 7
(12 27 2021)
ISSN: 1862-3514 [Electronic] England |
PMID | 34958402
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. International Osteoporosis Foundation and National Osteoporosis Foundation. |
Topics |
- Bone Density
- Female
- Humans
- Japan
(epidemiology)
- Osteoporosis
- Osteoporosis, Postmenopausal
(diagnostic imaging, drug therapy)
- Periodontal Diseases
(complications, drug therapy)
- Postmenopause
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