Synthesis and inhibitory activities of inhibitors for the treatment of Alzheimer's disease.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology and pathogenesis, in which butyrylcholinesterase (BuChE) plays an important role in the pathogenesis and progression. Inhibition of BuChE is a potential strategy for the treatment of advanced AD. Herein, the advantages and disadvantages of various synthesis methods on BuChE inhibitors and their inhibitory activities were summarized.

• Authors: Shiyang Zhou, Gangliang Huang
• Journal: Chemical biology & drug design (Chem Biol Drug Des) Vol. 99 Issue 5 Pg. 727-735 (05 2022) ISSN: 1747-0285 [Electronic] England
• PMID: 34942058 (Publication Type: Journal Article, Review)
• Copyright: © 2021 John Wiley & Sons A/S.

Chemical References

• Cholinesterase Inhibitors
• Acetylcholinesterase
• Butyrylcholinesterase

Topics

• Acetylcholinesterase
• Alzheimer Disease (drug therapy)
• Butyrylcholinesterase
• Cholinesterase Inhibitors (pharmacology, therapeutic use)
• Humans
• Neurodegenerative Diseases