Abstract | OBJECTIVE: Jian-Pi-Yi-Shen formula (JPYSF) is a traditional Chinese herbal decoction and has been used for treating chronic kidney disease (CKD) in clinics for decades. However, the potential mechanisms have not been fully elucidated. This study was designed to test the efficacy of JPYSF in treating CKD and explore the underlying mechanism. METHODS: RESULTS: The results show that administration of JPYSF significantly lowered Scr and BUN levels, improved renal tubular atrophy and interstitial fibrosis, and decreased renal extracellular matrix deposition in two CKD rat models. In addition, CKD rats exhibited suppressed QPRT/ NAD+/ SIRT3 signal, increased mitochondrial fission, and decreased mitochondrial fusion. JPYSF treatment promoted QPRT/ NAD+/ SIRT3 signal and restored mitochondrial fission/fusion balance. CONCLUSION: In conclusion, administration of JPYSF effectively alleviated CKD progression in two rat models, which may be related with regulation of the QPRT/ NAD+/ SIRT3/mitochondrial dynamics pathway.
|
Authors | Xinhui Liu, Siqi Liu, Bing Zhang, Denggui Luo, Shiying Huang, Fochang Wang, Lin Zheng, Jiandong Lu, Jianping Chen, Shunmin Li |
Journal | Evidence-based complementary and alternative medicine : eCAM
(Evid Based Complement Alternat Med)
Vol. 2021
Pg. 6625345
( 2021)
ISSN: 1741-427X [Print] United States |
PMID | 34938344
(Publication Type: Journal Article)
|
Copyright | Copyright © 2021 Xinhui Liu et al. |