Abstract | BACKGROUND: METHODS: Nuclear magnetic resonance (NMR) was used to evaluate serum lipid profiles, and lipoprotein particle number and size in nine androgen-treated individuals with DC, 45 untreated individuals with DC, 72 unaffected relatives of DC patients, and 19 untreated individuals with a different inherited BMF syndrome, Fanconi anaemia (FA). FINDINGS:
Androgen-treated individuals with DC had significantly decreased serum HDL cholesterol, HDL particle number and HDL particle size (p < 0·001, p < 0·001 and p < 0·001, respectively); significantly increased serum LDL cholesterol and LDL particle number (p < 0·001, p < 0·001, respectively), decreased apoA-I and increased apoB (p < 0⋅001, p < 0⋅05 respectively) when compared with untreated individuals with DC. There were no significant lipid profile differences between untreated DC and untreated FA participants; or between untreated DC participants and their unaffected relatives. Branched chain amino acids and lipoprotein insulin resistance were not significantly different with androgen treatment. GlycA, an inflammatory acute phase reactant, was significantly increased with androgen treatment (p < 0⋅001). INTERPRETATION: FUNDING: Intramural research programs of the Division of Cancer Epidemiology and Genetics of the National Cancer Institute and National Heart, Lung, and Blood Institute.
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Authors | Mone't B Thompson, Daniel Muldoon, Kelvin C de Andrade, Neelam Giri, Blanche P Alter, Sharon A Savage, Robert D Shamburek, Payal P Khincha |
Journal | EBioMedicine
(EBioMedicine)
Vol. 75
Pg. 103760
(Jan 2022)
ISSN: 2352-3964 [Electronic] Netherlands |
PMID | 34929494
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier B.V. |
Chemical References |
- Androgens
- Apolipoproteins B
- Lipoproteins
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Topics |
- Androgens
(adverse effects)
- Apolipoproteins B
- Dyskeratosis Congenita
(drug therapy, genetics, metabolism)
- Humans
- Lipoproteins
- Telomere
(metabolism)
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