Time in range, as an emerging metric of glycemic control, is associated with orthostatic blood pressure changes in type 2 diabetes.

Abstract

AIMS:

To exlpore whether time in range(TIR) was associated with orthostatic blood pressure(BP) changes in type 2 diabetes(T2DM).

METHODS:

A total of 342 T2DM patients were recruited. TIR was defined as the time percentage spent within the target range(3.9-10.0 mmol/L). Orthostatic hypotension(OH) and orthostatic hypertension(OHT) were defined as a decrease or an increase of at least 20 mmHg in SBP and/or 10 mmHg in DBP after standing for 3 min.

RESULTS:

Compared with orthostatic normotension group, patients with OH or OHT showed lower levels of TIR (P < 0.001). The prevalences of OH and OHT both decreased with ascending TIR tertiles (OH, P < 0.001; OHT, P = 0.019), and both absolute SBP and DBP changes were negatively correlated with TIR (r = -0.171, -0.190, P < 0.05). After stratifying by BMI, only the prevalence of OH in the lower layer and the prevalence of OHT in the higher layer remained significant difference among tertiles of TIR. Multivariate logistics regression revealed that lower TIR and lower BMI were risk factors for OH, whereas lower TIR but higher BMI were risk factors for OHT.

CONCLUSIONS:

We find a differential correlation dependent of BMI milieus between TIR and orthostatic BP status.

• Authors: Yanyu Yuan, Bin Lu, Qingyu Guo, Wei Wang, Zhouqin Feng, Xuguang Jin, Hui Zhou, Jun Liu, Haiyan Lei, Xinyi Yang, Jun Liu, Yanyu Liu, Jiaqing Shao, Ping Gu
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 183 Pg. 109179 (Jan 2022) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 34923020 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Topics

• Blood Pressure
• Diabetes Mellitus, Type 2 (complications, epidemiology)
• Glycemic Control
• Humans
• Hypertension (epidemiology)
• Hypotension, Orthostatic (epidemiology)