The
triglyceride glucose (TyG) index was regarded as a simple
surrogate marker of
insulin resistance (IR). It is confirmed that IR was significantly associated with
hyperuricemia, and
obesity was the risk factor for IR and
hyperuricemia. However, the relationship between the TyG index and
hyperuricemia and the potential role of
obesity in Han Chinese
hypertension are not entirely elucidated. A community-based cross-sectional study was conducted in 4551
hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting
triglyceride (mg/dl) × fasting plasma
glucose (mg/dl)/2].
Hyperuricemia was determined as serum
uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. Our study suggested that the TyG index was higher in patients with
hyperuricemia than in those without (8.99±0.61, 8.70±0.59, p < .001). The prevalence of
hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased
hyperuricemia risk whether in crude or adjusted models (p < .05). Mediation analysis showed that all of our
obesity indexes partially mediated the association between the TyG index and
hyperuricemia to some extent. In Conclusions, the TyG index is significantly associated with
hyperuricemia in
hypertension patients among Han Chinese,
obesity plays a partial mediation role in this relationship.