Abstract | OBJECTIVES: MATERIAL AND METHODS: RESULTS: Cephalometric values comprising the midface were decreased in Muenke syndrome (ANB: β = -1.87, p = 0.001; and PC1: p < 0,001), Saethre-Chotzen syndrome (ANB: β = -1.76, p = 0.001; and PC1: p < 0.001), and TCF12-related craniosynostosis (ANB: β = -1.70, p = 0.015; and PC1: p < 0.033). CONCLUSIONS: CLINICAL RELEVANCE: The maxillary growth in patients with Muenke syndrome, Saethre-Chotzen syndrome, or TCF12-related craniosynostosis is impaired, leading to a deviant dental development. Therefore, timely orthodontic follow-up is recommended. In order to increase expertise and support treatment planning by medical and dental specialists for these patients, and also because of the specific differences between the syndromes, we recommend the management of patients with Muenke syndrome, Saethre-Chotzen syndrome, or TCF12-related craniosynostosis in specialized multidisciplinary teams.
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Authors | T M Choi, O W Lijten, I M J Mathijssen, E B Wolvius, E M Ongkosuwito |
Journal | Clinical oral investigations
(Clin Oral Investig)
Vol. 26
Issue 3
Pg. 2927-2936
(Mar 2022)
ISSN: 1436-3771 [Electronic] Germany |
PMID | 34904178
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Basic Helix-Loop-Helix Transcription Factors
- TCF12 protein, human
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Topics |
- Acrocephalosyndactylia
- Adolescent
- Basic Helix-Loop-Helix Transcription Factors
- Cephalometry
- Child
- Child, Preschool
- Craniosynostoses
- Humans
- Syndrome
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