Abstract | BACKGROUND AND AIM: METHODS: We conducted searches on PubMed, Embase, and Cochrane. Data from eligible studies were used to calculate the pooled estimate of proportions of clinical remission, mucosal healing at Months 3, 6, 12, and 24 as well as the pooled incidence of adverse drug reactions. And subgroup analysis based on the specific type of anti-TNF agents was performed. RESULTS: Of the 828 studies initially identified, 13 were included finally, all of which were single-arm cohort studies. The pooled proportions of clinical remission at Months 3, 6, 12, and 24 were 0.61 (95%CI 0.48-0.78), 0.51 (95%CI 0.40-0.66), 0.57 (95%CI 0.48-0.67), and 0.38 (95%CI 0.16-0.88), respectively. The pooled proportions of mucosal healing at Months 3, 6, 12, and 24 were 0.66 (95%CI 0.50-0.86), 0.82 (95%CI 0.48-0.98), 0.65 (95%CI 0.51-0.81), and 0.69 (95%CI 0.39-1.00), respectively. The pooled estimate of proportion of overall adverse drug reactions for infliximab was 0.22 (95%CI 0.07-0.69). CONCLUSIONS:
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Authors | Mengyuan Zhang, Jinjing Liu, Tingting Liu, Wei Han, Xiaoyin Bai, Gechong Ruan, Hong Lv, Huijun Shu, Yue Li, Ji Li, Bei Tan, Weiyang Zheng, Hui Xu, Wenjie Zheng, Hong Yang, Jiaming Qian |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 37
Issue 4
Pg. 608-619
(Apr 2022)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 34894004
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Tumor Necrosis Factor Inhibitors
- Tumor Necrosis Factor-alpha
- Infliximab
- Adalimumab
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Topics |
- Adalimumab
(adverse effects)
- Behcet Syndrome
(drug therapy, pathology)
- Humans
- Infliximab
(adverse effects)
- Treatment Outcome
- Tumor Necrosis Factor Inhibitors
- Tumor Necrosis Factor-alpha
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