A patient with Turner syndrome received the percutaneous vertebroplasty seven times: a case report and literature review.

Abstract

BACKGROUND:

Turner syndrome (TS) is characterized as the complete or partial absence of one X chromosome and is an extremely rare disease affecting approximately 1:2500 live female births. Though the prevalence of osteoporosis among women with TS is estimated to be around 55-64% and they suffer more frequently from fractures than normal, few reports concerning TS patients with osteoporosis are able to be seen due to tiny number of patients.

CASE PRESENTATION:

Here, we report a rare case of TS with osteoporosis, who has undergone percutaneous vertebroplasty (PVP) seven times because of several vertebral compression fractures (VCFs). G-banded karyotype analysis was performed and the result was 45,X[43]/47,XXX[17], indicating that the patient was a mosaicism of TS karyotype and Trisomy X syndrome karyotype. TS is the underlying cause of low level of estrogen for this patient. The interaction of aging, estrogen deficiency and intestinal dysbacteriosis leads to her severe osteoporosis and multi-segmental VCFs. The aim of this report is to provide recommendations regarding the management of TS patients with osteoporosis by reviewing the clinical presentation of TS, the influence of estrogen deficiency in osteoporosis, etc. CONCLUSIONS: Early diagnosis and hormone replacement treatment are essential for TS patients to prevent osteoporosis and reduce the risk of fractures. This is a rare case report describing TS patient with severe osteoporosis and VCFs.

• Authors: Longyu Li, Yifang Shi, Nan Zhao, Zhengpei Liu, Zhe Zhao, Zongmian Song, Sailei Zheng, Miaoheng Yan, Zikuan Leng, Songfeng Chen, Guowei Shang, Hongwei Kou, Hongjian Liu
• Journal: European journal of medical research (Eur J Med Res) Vol. 26 Issue 1 Pg. 139 (Dec 07 2021) ISSN: 2047-783X [Electronic] England
• PMID: 34876225 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: © 2021. The Author(s).

Topics

• Aged
• Female
• Fractures, Compression (diagnosis, etiology)
• Humans
• Osteoporotic Fractures (diagnosis, etiology, surgery)
• Radiography
• Reoperation (statistics & numerical data)
• Thoracic Vertebrae (diagnostic imaging, injuries, surgery)
• Turner Syndrome (complications, diagnosis, genetics)
• Vertebroplasty (adverse effects)