Abstract | BACKGROUND: Because the effect of low molecular heparin (LMH) on acute ulcer and bleeding complications in patients with severe acute pancreatitis (SAP) is unclear, we investigated the safety and efficacy of early intervention with LMH in patients with SAP. METHODS: RESULTS: A total of 8 references were included in the study, and most of them were low risk bias (medium and high quality). Meta-analysis shows that, The MHS between the two groups is statistically heterogeneous. (Chi2=19.59, I2=95%, P<0.00001), Fixed-effects model (FEM) analysis showed that the MHS of experimental subjects was obviously shorter than that of controls (Z=3.24, P=0.001); The acute physiology and chronic health score (APACHE II) of the two groups were heterogeneous (Chi2=7.24, I2=72%, P=0.03); No heterogeneity was found in the amount of bleeding (Chi2=5.83, I2=31%, P=0.21), FEM analysis showed the number of complications in the experimental group was significantly less than that in the control group (Z=2.70, P=0.007). DISCUSSION: LMH intervention can dramatically reduce the average hospital stay and complications of patients with SAP, improve treatment efficacy, and has high safety.
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Authors | Hui Wang, Ying Xu, Meijuan Yang, Dexing Zheng, Lijiao Chen |
Journal | Annals of palliative medicine
(Ann Palliat Med)
Vol. 10
Issue 11
Pg. 11695-11704
(Nov 2021)
ISSN: 2224-5839 [Electronic] China |
PMID | 34872294
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
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Topics |
- Acute Disease
- Heparin
(adverse effects)
- Humans
- Length of Stay
- Pancreatitis
(drug therapy)
- Treatment Outcome
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