Zinc Oxide Nanoparticles Ameliorate Dimethylnitrosamine-Induced Renal Toxicity in Rat.

Abstract

Dimethylnitrosamine (DMN) is an established carcinogen. It is toxic to several organs, viz., the liver, kidney, and lungs, and immune system. Several drugs have been used in the past to modulate its toxicity using experimental animal models. The present study was designed to investigate the effect of zinc oxide nanoparticles (ZnONPs) on renal toxicity caused by DMN in laboratory rat. Since oxidative mechanisms are mainly involved in its toxicity, the proposed study focuses on the amelioration of oxidative stress response by ZnONPs, if any. The present results show that administration of ZnONPs (50 mg/kg body weight/rat) to DMN (2 μl/100 g body weight/rat)-treated rats diminuted the concentration of malonaldehyde, H2O2, and NO in the kidney. However, reduced glutathione (GSH) concentration increased after ZnONP treatment. Results on glutathione S-transferase and glutathione peroxidase favored its antioxidative effects. These results are supported by the recovery of oxidative DNA damage and less pronounced histopathological changes in the kidney. It is hypothesized that ZnONPs might be toxic to renal tissue; however, its strong therapeutic/antioxidative potential helps in ameliorating DMN-induced renal toxicity in rat.

• Authors: Varsha Rani, Yeshvandra Verma, S V S Rana
• Journal: Applied biochemistry and biotechnology (Appl Biochem Biotechnol) Vol. 194 Issue 4 Pg. 1699-1715 (Apr 2022) ISSN: 1559-0291 [Electronic] United States
• PMID: 34855113 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Antioxidants
• Hydrogen Peroxide
• Dimethylnitrosamine
• Zinc Oxide

Topics

• Animals
• Antioxidants (pharmacology)
• Body Weight
• Dimethylnitrosamine (pharmacology)
• Hydrogen Peroxide (pharmacology)
• Nanoparticles
• Oxidative Stress
• Rats
• Zinc Oxide (toxicity)