Abstract | BACKGROUND:
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy ( HIPEC) is the best effective treatment for pseudomyxoma peritonei (PMP). In the last years, the advances in histopathology have stratified PMP lesions in different degrees of aggressivity suggesting the possibility of a tailored treatment. In a subset of patients with small volume peritoneal disease, laparoscopic CRS and HIPEC is feasible. The aim of this study is to analyze the results of laparoscopic CRS + HIPEC in a monocentric series of patients under patient-related experience measures (PREMs). METHODS: All consecutive patients who underwent laparoscopic CRS- HIPEC with curative intent at Cancer Institute of Montpellier were retrieved from a prospectively maintained database and analyzed. Selection criteria for laparoscopic approach were low-grade PMP with pathological confirmation prior to CRS- HIPEC, age < 75 years, no extra- peritoneal disease, peritoneal cancer index (PCI) < 10, and a limited history of abdominal surgery. A PREMS interview was conducted before analysis with all the included patients. Outcomes of interest included postoperative morbidity, medium-term survival, and PREMs. RESULTS: Fourteen patients were operated on for low-grade PMP with a laparoscopic approach at our institution. Conversions to laparotomy were necessary in three patients, and postoperative complications were observed in three patients (Clavien 3b in one patient). In-hospital postoperative median stay was 9.5 days. No death or recurrence was observed during the study period. CONCLUSIONS: Laparoscopic CRS- HIPEC for LAMN in presence of small peritoneal disease is feasible in terms of postoperative morbidity and mortality. According to our PREMs questionnaire, patients' expectations were satisfied.
|
Authors | Caterina Cusumano, Sébastien Carrere, Alix Bouillin, Stéphanie Nougaret, Lakhdar Khellaf, François Quénet, Olivia Sgarbura |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 36
Issue 7
Pg. 4757-4763
(07 2022)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 34845545
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Topics |
- Aged
- Combined Modality Therapy
- Cytoreduction Surgical Procedures
(methods)
- Humans
- Hyperthermia, Induced
- Hyperthermic Intraperitoneal Chemotherapy
- Laparoscopy
- Peritoneal Diseases
- Peritoneal Neoplasms
(drug therapy)
- Pseudomyxoma Peritonei
(surgery)
- Retrospective Studies
|