Ivabradine-Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review.

Abstract

Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ectopic tachycardia (JET), both congenital and postoperative, and describe the successful use of ivabradine-flecainide association for CJET therapy resistant to other antiarrhythmic agents. This new drug combination was effective in completely suppressing JET. Ivabradine-flecainide combination may be considered a new therapeutic strategy of CJET with a satisfactory efficacy/tolerability ratio in patients resistant to conventional drug combinations.

• Authors: Giovanni Maria Di Marco, Angelica De Nigris, Angela Pepe, Annamaria Pagano, Giangiacomo Di Nardo, Vincenzo Tipo
• Journal: Pediatric reports (Pediatr Rep) Vol. 13 Issue 4 Pg. 624-631 (Nov 23 2021) ISSN: 2036-749X [Print] Switzerland
• PMID: 34842781 (Publication Type: Case Reports)