Abstract | BACKGROUND: METHODS: Fifty pediatric HUS patients and 50 age- and sex-matched controls were included in the study. Patients were subjected to full history taking, clinical examination, and laboratory testing. All candidates were subjected to an assessment of anti-FH in serum by a homemade enzyme-linked immunosorbent assay technique. RESULTS: A high frequency of serum anti-FH was detected in our aHUS patients. The disease onset of AI-HUS was mainly observed in March and April, with significantly higher rates in school-aged males. All patients who started immunosuppressives early together with plasmapheresis upon detection of their anti-FH had complete renal function recovery. CONCLUSION: The high frequency of AI-HUS revealed in Egyptian HUS children in our study highlights the importance of implementing anti-FH testing in Egypt to provide early recognition for immediate proper management, including early immunosuppressive therapy, and hence improving patient outcomes.
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Authors | Shereen Shawky, Hesham Safouh, Mona Gamal, Mohammed M Abbas, Azza Aboul-Enein, Toshihiro Sawai, Yosra Fahmy, Heba Selim |
Journal | International journal of nephrology
(Int J Nephrol)
Vol. 2021
Pg. 6904858
( 2021)
ISSN: 2090-214X [Print] United States |
PMID | 34840826
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Shereen Shawky et al. |