Pipeline flex embolization device for the treatment of large unruptured posterior circulation aneurysms: Single-center experience.

Abstract

PURPOSE:

To investigate the safety and effect of the Pipeline Embolization Device (PED) Flex device in the treatment of large unruptured posterior circulation aneurysms in a single center.

MATERIALS AND METHODS:

Patients with large unruptured posterior circulation aneurysms which were treated with the PED Flex device were enrolled. The clinical, endovascular and follow-up data were analyzed, and the O'Kelly-Marotta (OKM) grading system was used to assess the aneurysm occlusion status.

RESULTS:

Fourteen patients with 14 large posterior circulation aneurysms who were treated with the PED Flex device were enrolled. The maximal diameter of aneurysm was 17.0 ± 3.9 mm. Fourteen PED Flex devices were deployed in 14 patients, with a technical success rate of 100%. All stents covered the aneurysm neck with good wall adherence and patent parent artery. Ten (71.4%) aneurysms were treated with a single PED Flex device each, and four (28.6%) patients experienced additional coiling. No neurological complications occurred in the periprocedural period. The mRS was 0 in eleven (78.6%) patients, 1 in two (14.3%), and 2 in one (7.1%) at discharge. All patients were followed up at 6-28 months (median 18), with an mRS score of 0 in all patients. Twelve (85.7%) patients experienced digital subtraction angiography 6-28 (median 18) months after the embolization procedure, and the OKM grade was D in nine (75%), C in two (16.7%), and B in one (8.3%).

CONCLUSION:

The Pipeline Flex Embolization Device can be safely applied to treat large unruptured posterior circulation aneurysms with a high complete aneurysm occlusion rate at follow-up.

• Authors: Li Li, Bu-Lang Gao, Qiao-Wei Wu, Qiu-Ji Shao, Zi-Liang Wang, Kun Zhang, Tian-Xiao Li
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 96 Pg. 127-132 (Feb 2022) ISSN: 1532-2653 [Electronic] Scotland
• PMID: 34838429 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Topics

• Blood Vessel Prosthesis
• Embolization, Therapeutic (adverse effects)
• Humans
• Intracranial Aneurysm (diagnostic imaging, therapy)
• Retrospective Studies
• Treatment Outcome