Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases.

Abstract

Ursolic acid (UA) is a pentacyclic triterpenoid frequently found in medicinal herbs and plants, having numerous pharmacological effects. UA and its analogs treat multiple diseases, including cancer, diabetic neuropathy, and inflammatory diseases. UA inhibits cancer proliferation, metastasis, angiogenesis, and induced cell death, scavenging free radicals and triggering numerous anti- and pro-apoptotic proteins. The biochemistry of UA has been examined broadly based on the literature, with alterations frequently having been prepared on positions C-3 (hydroxyl), C12-C13 (double bonds), and C-28 (carboxylic acid), leading to several UA derivatives with increased potency, bioavailability and water solubility. UA could be used as a protective agent to counter neural dysfunction via anti-oxidant and anti-inflammatory effects. It is a potential therapeutic drug implicated in the treatment of cancer and diabetic complications diseases provide novel machinery to the anti-inflammatory properties of UA. The pharmacological efficiency of UA is exhibited by the therapeutic theory of one-drug → several targets → one/multiple diseases. Hence, UA shows promising therapeutic potential for cancer and diabetic neuropathy diseases. This review aims to discuss mechanistic insights into promising beneficial effects of UA. We further explained the pharmacological aspects, clinical trials, and potential limitations of UA for the management of cancer and diabetic neuropathy diseases.

• Authors: Manzar Alam, Sabeeha Ali, Sarfraz Ahmed, Abdelbaset Mohamed Elasbali, Mohd Adnan, Asimul Islam, Md Imtaiyaz Hassan, Dharmendra Kumar Yadav
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 22 (Nov 10 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 34830043 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents, Phytogenic
• Triterpenes

Topics

• Anti-Inflammatory Agents (chemistry, therapeutic use)
• Antineoplastic Agents, Phytogenic (chemistry, therapeutic use)
• Diabetic Neuropathies (drug therapy)
• Humans
• Neoplasms (drug therapy)
• Plants, Medicinal (chemistry)
• Triterpenes (chemistry, therapeutic use)
• Ursolic Acid