Abstract |
It is still a huge challenge for concurrent highly efficient loading of chemotherapeutic agent and photosensitizer into single nanocarrier via stimuli-responsive linkages due to their different physicochemical properties and pharmacokinetics. Herein, based on the discovery of unique cisplatin- hydrazide and cisplatin- indocyanine green (ICG) coordination reactions, a multifunctional coordination nanoprodrug, cisplatin/ICG co-loaded hydrazided hyaluronan/ bovine serum albumin (HBCI) nanoparticles, was developed by a desolvation-dual coordination process. The nanoprodrug exhibited ultrahigh drug loading efficiency and glutathione/NIR light dual-responsive drug release behavior. In vitro cellular studies demonstrated efficient internalization and apoptosis-inducing ability of the nanoprodrug in HepG2 cells. In vivo results confirmed the efficacious tumor accumulation and biosafety of HBCI nanoprodrug and synergistic effect of HBCI-based combined photodynamic chemotherapy on inhibiting tumor growth. Overall, this work not only provides a novel dual coordination approach for highly efficient loading of cisplatin and ICG but also verifies the therapeutic potential of HBCI nanoprodrug in combating hepatocellular carcinoma.
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Authors | Guanghui Hou, Junmin Qian, Min Guo, Weijun Xu, Jinlei Wang, Yaping Wang, Aili Suo |
Journal | Carbohydrate polymers
(Carbohydr Polym)
Vol. 276
Pg. 118810
(Jan 15 2022)
ISSN: 1879-1344 [Electronic] England |
PMID | 34823812
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Photosensitizing Agents
- Prodrugs
- Hyaluronic Acid
- Indocyanine Green
- Cisplatin
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Cisplatin
(chemistry, pharmacology)
- Drug Delivery Systems
(methods)
- Hep G2 Cells
- Humans
- Hyaluronic Acid
(chemistry, pharmacology)
- Indocyanine Green
(chemistry, pharmacology)
- Liver Neoplasms
(drug therapy, metabolism)
- Male
- Mice
- Mice, Inbred BALB C
- Nanoparticles
(chemistry)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(chemistry, pharmacology)
- Prodrugs
(chemistry, pharmacology)
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