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Hydrazided hyaluronan/cisplatin/indocyanine green coordination nanoprodrug for photodynamic chemotherapy in liver cancer.

Abstract
It is still a huge challenge for concurrent highly efficient loading of chemotherapeutic agent and photosensitizer into single nanocarrier via stimuli-responsive linkages due to their different physicochemical properties and pharmacokinetics. Herein, based on the discovery of unique cisplatin-hydrazide and cisplatin-indocyanine green (ICG) coordination reactions, a multifunctional coordination nanoprodrug, cisplatin/ICG co-loaded hydrazided hyaluronan/bovine serum albumin (HBCI) nanoparticles, was developed by a desolvation-dual coordination process. The nanoprodrug exhibited ultrahigh drug loading efficiency and glutathione/NIR light dual-responsive drug release behavior. In vitro cellular studies demonstrated efficient internalization and apoptosis-inducing ability of the nanoprodrug in HepG2 cells. In vivo results confirmed the efficacious tumor accumulation and biosafety of HBCI nanoprodrug and synergistic effect of HBCI-based combined photodynamic chemotherapy on inhibiting tumor growth. Overall, this work not only provides a novel dual coordination approach for highly efficient loading of cisplatin and ICG but also verifies the therapeutic potential of HBCI nanoprodrug in combating hepatocellular carcinoma.
AuthorsGuanghui Hou, Junmin Qian, Min Guo, Weijun Xu, Jinlei Wang, Yaping Wang, Aili Suo
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 276 Pg. 118810 (Jan 15 2022) ISSN: 1879-1344 [Electronic] England
PMID34823812 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Photosensitizing Agents
  • Prodrugs
  • Hyaluronic Acid
  • Indocyanine Green
  • Cisplatin
Topics
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • Cisplatin (chemistry, pharmacology)
  • Drug Delivery Systems (methods)
  • Hep G2 Cells
  • Humans
  • Hyaluronic Acid (chemistry, pharmacology)
  • Indocyanine Green (chemistry, pharmacology)
  • Liver Neoplasms (drug therapy, metabolism)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles (chemistry)
  • Photochemotherapy (methods)
  • Photosensitizing Agents (chemistry, pharmacology)
  • Prodrugs (chemistry, pharmacology)

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