Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice.
|
| Abstract |
BSH-1 is an O-acetylated xylan obtained from bamboo shavings. This study determined the protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice. Mice received BSH-1 by gavage daily for 14 days. In constipated mice, BSH-1 significantly shortened the defecation time and raised the gastrointestinal (GI) transit rate, stool production, and cecal concentration of short-chain fatty acids (SCFAs). BSH-1 regulated the serum levels of gut hormones and neurotransmitters. BSH-1 also significantly altered the cecal microbiota of the constipated mice by increasing the abundance of potentially beneficial bacteria (e.g., Lactobacillus, Roseburia, and Bacteroidales_S24-7) and decreasing potentially pathogenic bacteria (e.g., Alloprevotella and Staphylococcus). Furthermore, colonic transcriptome analysis revealed that BSH-1 significantly reversed the expression changes of genes related to intestinal motility, water and ion transport, inflammation and cancer in constipated mice. Our findings indicated that BSH-1 effectively relieved Lop-induced constipation in mice and could be potentially used for constipation treatment.
|
|---|---|
| Authors | Juqing Huang, Bin Lin, Ying Zhang, Zhenglu Xie, Yi Zheng, Qi Wang, Hang Xiao |
| Journal | Carbohydrate polymers (Carbohydr Polym) Vol. 276 Pg. 118761 (Jan 15 2022) ISSN: 1879-1344 [Electronic] England |
| PMID | 34823784 (Publication Type: Journal Article) |
| Copyright | Copyright © 2021. Published by Elsevier Ltd. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!