Interaction of high-intensity endurance exercise and nandrolone on cardiac remodeling: role of adipo-cardiac axis.

Abstract

OBJECTIVES:

Given the cardiac pathological remodeling following to anabolic androgenic steroids (AASs) consumption, we examined the effect of chronic administration of nandrolone decanoate with high-intensity endurance exercise on the left ventricular hypertrophy index, levels of hydroxyproline, tumor necrosis factor-alpha (TNF-α), adiponectin (APN) and its receptors (AdipoR1 and AdipoR2) expression in rats' hearts.

METHODS:

The male Wistar rats randomly divided to six groups included the control (CTL), exercise (Ex), nandrolone (Nan), vehicle (Arach), trained vehicle (Ex + Arach), and trained nandrolone (Ex + Nan) groups that were treated for eight weeks.

RESULTS:

Nandrolone consumption significantly enhanced the hypertrophy index (p<0.05) and exercise intensified this effect. It also increased the level of cardiac hydroxyproline (p<0.001), however exercise completely masked this effect. The values of TNF-α protein and AdipoR1 protein significantly increased in trained nandrolone-treated (Ex + Nan) group in comparison with CTL group (p<0.05), however, did not show significant alteration in Nan or Ex groups. High-intensity endurance exercise significantly enhanced the AdipoR2 protein (p<0.05), but, co-administration of nandrolone with exercise prevented this effect. The mRNA expression of AdipoR1 significantly reduced in the animals that received nandrolone for eight weeks and exercise recovered this effect (p<0.001).

CONCLUSIONS:

Despite an additive effect of high-intensity endurance exercise plus nandrolone on TNF-α level, their effects on hydroxyproline and APN receptors expression is incompatible in heart of rat. It is suggests a part of beneficial regulatory role of endurance exercise against nandrolone induced heart remodeling may apply through modulation of APN system.

• Authors: Manijeh Motevalian, Siyavash Joukar, Saeed Esmaeili-Mahani, Abdollah Karimi, Yaser Masoumi-Ardakani, Sepideh Safari
• Journal: Hormone molecular biology and clinical investigation (Horm Mol Biol Clin Investig) Vol. 43 Issue 1 Pg. 63-70 (Nov 16 2021) ISSN: 1868-1891 [Electronic] Germany
• PMID: 34786896 (Publication Type: Journal Article)
• Copyright: © 2021 Walter de Gruyter GmbH, Berlin/Boston.

Chemical References

• Nandrolone

Topics

• Animals
• Heart
• Male
• Nandrolone (pharmacology)
• Physical Conditioning, Animal
• Rats
• Rats, Wistar
• Ventricular Remodeling