Abstract | SCOPE: METHODS AND RESULTS: Low- and high-oxidative injury pork (LOP and HOP) are freeze-dried to prepare mouse diets. Mice are fed a diet of either the control, LOP, HOP, LOP+Dityr, or Dityr for 12 weeks. HOP and Dityr intake induced oxidative stress and inflammation that impaired thyroid function and peripheral metabolism (reduced type 1 deiodinase activity) of thyroid hormones (THs). These lead to a decrease in the circulating as well as liver THs and induced hepatic steatosis. This process might be regulated through reduced TH levels and altered TH target genes and proteins related to hepatic lipid metabolism that ultimately inhibited hepatic energy metabolism, as indicated by increased hepatic lipid synthesis, decreased hepatic lipid catabolism, and fatty acid oxidation. CONCLUSION: HOP intake could induce hepatic steatosis by impairing TH function. Dityr plays an important role in the HOP-induced harmful effects.
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Authors | Yueting Ge, Yuhui Yang, Yuge Jiang, Chuanxing Feng, Bowen Li, Jin Sun, Xue Tang, Yonghui Shi, Guowei Le |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 66
Issue 1
Pg. e2100602
(01 2022)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 34786857
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 Wiley-VCH GmbH. |
Chemical References |
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Topics |
- Animals
- Lipid Metabolism
- Liver
(metabolism)
- Mice
- Mice, Inbred C57BL
- Non-alcoholic Fatty Liver Disease
(etiology, metabolism)
- Pork Meat
- Red Meat
- Swine
- Thyroid Gland
(metabolism)
- Thyroid Hormones
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