Intellectual development of patients with biliary atresia who underwent living donor liver transplantation in infancy.

Abstract

BACKGROUND:

The impact of pediatric liver transplantation on intellectual development has yet to be determined. We investigated the intellectual outcomes of school-aged patients after living donor liver transplantation for biliary atresia in infancy.

METHODS:

The Wechsler Intelligence Scale for Children-fourth edition test was administered to 20 patients who survived [Formula: see text] 5 years after living donor liver transplantation. Borderline full scale intelligence quotient was defined as ≤ 85. Pre-, peri-, and postoperative data were compared between patients with > 85 and ≤ 85 to identify predictive factors of borderline performance.

RESULTS:

The one-sample t test demonstrated that the mean full scale intelligence quotient of patients after transplantation for biliary atresia was significantly lower than that of the general population (91.8 vs. 100.0, p = 0.026) and 7 (35%) were classified as intellectual borderline functioning. Multivariable logistic regression models were unable to identify any factors predictive of full scale intelligence quotients of ≤ 85.

CONCLUSION:

This is the first study to indicate that the mean full scale intelligence quotient among school-aged patients who underwent living donor liver transplantation for biliary atresia in infancy is significantly lower than that of the general population.

• Authors: Seiichi Kawabata, Rieko Sakamoto, Keiichi Uto, Tomoaki Irie, Masashi Kadohisa, Keita Shimata, Yasuko Narita, Kaori Isono, Masaki Honda, Shintaro Hayashida, Yuki Ohya, Hidekazu Yamamoto, Hirotoshi Yamamoto, Miwako Nakano, Yasuhiko Sugawara, Yukihiro Inomata, Taizo Hibi
• Journal: Pediatric surgery international (Pediatr Surg Int) Vol. 38 Issue 2 Pg. 201-208 (Feb 2022) ISSN: 1437-9813 [Electronic] Germany
• PMID: 34779867 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Topics

• Biliary Atresia (surgery)
• Child
• Humans
• Liver Transplantation
• Living Donors
• Logistic Models
• Postoperative Period