Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone.

Abstract

The most common causes of hypercalcemia are primary hyperparathyroidism (PHPT) and malignancy. Parathyroid carcinoma (PC), causing a severe PHPT, is the rarest parathyroid tumor. A diagnosis of PC is challenging because the clinical profile overlaps with that of benign counterpart. Surgery is the mainstay treatment. CDC73 mutations have been detected in up to 80% of sporadic PCs. Ectopic production of parathyroid hormone (PTH) by malignant nonparathyroid tumors is a rare condition accounting for less than 1% of hypercalcemia of malignancy. PTH secretion can be considered an aberration in the tissue specificity of gene expression and may involve heterogeneous molecular mechanisms.

• Authors: Filomena Cetani, Elena Pardi, Claudio Marcocci
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 50 Issue 4 Pg. 683-709 (12 2021) ISSN: 1558-4410 [Electronic] United States
• PMID: 34774241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Parathyroid Hormone

Topics

• Humans
• Hypercalcemia (etiology)
• Parathyroid Hormone
• Parathyroid Neoplasms (complications, diagnosis, genetics)