Transplantation of acellularized dermis matrix (ADM) plus fully covered metal stent to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer (with video).

Abstract

BACKGROUD AND STUDY AIMS:

Esophageal stricture is a serious adverse event occurring after circular endoscopic submucosal dissection (ESD) involving the whole esophagus. However, there is still a lack of effectively preventive methods. The main purpose of this study is to evaluate the efficacy of application of acellularized dermis matrix (ADM) for the prevention of post-ESD esophageal stricture. The main objective of this study was to evaluate the use of decellularized dermal matrix (ADM) in the prevention of post-esophageal ESD strictures.

PATIENTS AND METHODS:

A pilot, single-center, prospective study was conducted. The study enrolled seven patients who had high-risks with extended resection of developing post-ESD esophageal stricture. After undergoing ESD, we attached different size of ADM patches to the mucosal defects using titanium clips then fixed with a metal mesh stent. The stent covered with metal mesh was removed at the median time of 27 days after the endoscopic procedure. Follow-up and repeated outpatient endoscopic screening were performed at appropriate scheduled times.

RESULTS:

The average longitudinal diameter of the resected specimens was 58.3 mm (range 38-90 mm). There were three patients developing strictures postoperatively at a mean time of 87 days (range 42-140). The median number of postoperative endoscopic balloon dilatation (EBD) in patients with stenosis was 2 (range 2-9). There were no deaths during a median follow-up period of 6 moths (range 1-12).

CONCLUSIONS:

This study was performed to assess the efficacy and safe method of relieving the severity of esophageal stricture after ESD through transplantation of ADM.

• Authors: Xian-Bin Zhou, Shao-Wei Li, Sai-Qin He, Shan-Jing Xu, Yue Cai, Shi-Wen Xu, Xiao-Kang Li, Bin-Bin Gu, Xin-Li Mao, Li-Ping Ye
• Journal: Regenerative therapy (Regen Ther) Vol. 18 Pg. 441-446 (Dec 2021) ISSN: 2352-3204 [Electronic] Netherlands
• PMID: 34754889 (Publication Type: Journal Article)
• Copyright: © 2021 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.