Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis.

Abstract

Spinal cord ischemia/reperfusion (SCI/R) injury is a devastating complication usually occurring after thoracoabdominal aortic surgery. However, it remains unsatisfactory for its intervention by using pharmacological strategies. Oxidative stress is a main pharmacological process involved in SCI/R, which will elicit downstream programmed cell death such as the novel defined necroptosis. Astragalin is a bioactive natural flavonoid with a wide spectrum of pharmacological activities. Herein, we firstly evaluated the effect of astragalin to oxidative stress as well as the possible downstream necroptosis after SCI/R in mice. Our results demonstrated that astragalin improves the ethological score and histopathological deterioration of SCI/R mice. Astragalin mitigates oxidative stress and ameliorates inflammation after SCI/R. Astragalin blocks necroptosis induced by SCI/R. That is, the amelioration of astragalin to the motoneuron injury and histopathological changes. Indicators of oxidative stress, inflammation, and necroptosis after SCI/R were significantly blocked. Summarily, we firstly illustrated the protection of astragalin against SCI/R through its blockage to the necroptosis at downstream of oxidative stress.

• Authors: Feng Sun, Haiwei Zhang, Jianhui Shi, Tianwen Huang, Yansong Wang
• Journal: BioMed research international (Biomed Res Int) Vol. 2021 Pg. 7254708 ( 2021) ISSN: 2314-6141 [Electronic] United States
• PMID: 34746308 (Publication Type: Journal Article, Retracted Publication)
• Copyright: Copyright © 2021 Feng Sun et al.

Chemical References

• Antioxidants
• Flavonoids
• Kaempferols
• Neuroprotective Agents
• astragalin

Topics

• Animals
• Antioxidants (metabolism)
• Apoptosis (drug effects)
• Flavonoids (pharmacology)
• Inflammation (drug therapy)
• Kaempferols (metabolism, pharmacology)
• Male
• Mice
• Mice, Inbred C57BL
• Models, Animal
• Necroptosis (drug effects, physiology)
• Neuroprotective Agents (pharmacology)
• Oxidative Stress (drug effects, physiology)
• Reperfusion Injury (drug therapy, metabolism)
• Spinal Cord (physiopathology)
• Spinal Cord Injuries (physiopathology)
• Spinal Cord Ischemia (complications, drug therapy, physiopathology)