[Research progress in pharmacology and toxicology of evodiamine].

Abstract

Evodiamine, a bioactive indole alkaloid from Evodia rutaecarpa, E. rutaecarpa var. officinalis, or E. rutaecarpa var. bodinieri, has been extensively investigated due to its pharmacological activities in recent years. At present, evodiamine is proved to significantly suppress the proliferation of a variety of cancer cells and mediate cell processes such as cell cycle arrest and cell migration. In addition, evodiamine displays significant pharmacological activities against cardiovascular diseases(hyperlipidemia, etc.), and tinea manus and pedis. Recently, evodiamine has been found to have potential toxic effects, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. However, the pharmacological and toxicological mechanism of evodiamine is not clear, and its toxicity in vitro and in vivo has been rarely reported. Therefore, this study reviewed the pharmacological and toxicological articles of evodiamine in recent years, aiming at providing new ideas and references for future research.

• Authors: Chun-Qi Yang, Wen-Yu Lian, Yu-Guang Wang, Yue Gao
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 46 Issue 20 Pg. 5218-5225 (Oct 2021) ISSN: 1001-5302 [Print] China
• PMID: 34738422 (Publication Type: Journal Article)

Chemical References

• Plant Extracts
• Quinazolines
• evodiamine

Topics

• Evodia
• Hand Dermatoses
• Humans
• Plant Extracts
• Quinazolines (toxicity)
• Tinea