[Influence of pantogam and atomoxetine on attention stability and distribution of dopamine D2 and GABAB receptors in the attention deficit mouse model].

Abstract

The closed enriched cross maze test was employed as a new experimental model of the attention deficit disorder (ADD) for evaluation of the behavioral and neurochemical effects of the nootropic drug pantogam (100 mg/kg, intraperitoneally) and atomoxetine hydrochloride (3 mg/kg, intraperitoneally) administered subchronically to CD-1 outbred mice. Two subpopulations of rodents differed spontaneously in attention to enriched compartments (ED-Low and ED-High), were estimated on the basis of time spent by the mice in the empty or enriched compartments. The ED-Low and ED-High mice insignificantly differed in parameters associated with anxiety, exploratory efficacy and motor activity. Subchronic administration of both drugs in selected doses produced corrective effect on animal behavior seen as a selective increase in the ED-ratio values in the ED-Low subpopulation. Differences in the distribution of dopamine D2 and GABAB receptors (Bmax) between placebo-treated ED-Low and ED-High mice were found in the prefrontal cortex using the radioligand binding method. The neuroreceptor effects of atomoxetine were seen in prefrontal cortex of ED-Low mice as decrease in the Bmax values of D2 receptors by 14%. Pantogam in the prefrontal cortex of ED-Low subpopulation showed a decrease in the Bmax values of D2 receptors by 22% and an increase for GABAB receptors by 44%. Therefore, subchronic administration of pantogam had a positive corrective effect on the behavior parameters and the density of the studied receptor subtypes in animals with severe attention deficit.

• Authors: G I Kovalev, N A Sukhorukova, E V Vasileva, E A Kondrakhin, R M Salimov
• Journal: Biomeditsinskaia khimiia (Biomed Khim) Vol. 67 Issue 5 Pg. 402-410 (Sep 2021) ISSN: 2310-6972 [Print] Russia (Federation)
• Vernacular Title: Vliianie pantogama i atomoksetina na ustoĭchivost' vnimaniia i raspredelenie dofaminovykh D2 i GAMKV-retseptorov u mysheĭ s model'iu defitsita vnimaniia.
• PMID: 34730553 (Publication Type: Journal Article)

Chemical References

• pantogab
• Pantothenic Acid
• gamma-Aminobutyric Acid
• Atomoxetine Hydrochloride
• Dopamine

Topics

• Animals
• Atomoxetine Hydrochloride (pharmacology)
• Attention Deficit Disorder with Hyperactivity (drug therapy)
• Dopamine
• Mice
• Pantothenic Acid (analogs & derivatives)
• gamma-Aminobutyric Acid (analogs & derivatives)