Biomarkers of subclinical atherosclerosis in patients with psoriasis.

Abstract

Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by use of a proximity extension assay in 85 patients with a history of moderate-to-severe psoriasis with or without established atherosclerotic CVD. Differentially expressed proteins associated with CVD were correlated with subclinical atherosclerotic markers including vascular inflammation determined by 18F-fluorodeoxyglucose positron emission tomography/computed tomography, carotid intima-media thickness (CIMT), carotid artery plaques, and coronary artery calcium score (CCS) in the patients without CVD and statin treatment. We also examined the association between the neutrophil-to-lymphocyte ratio (NLR) and subclinical atherosclerosis. In unadjusted analyses, growth differentiation factor-15 (GDF-15) levels and NLR were increased, while tumor necrosis factor (TNF)-related activation-inducing ligand (TRANCE) and TNF-related apoptosis-induced ligand (TRAIL) levels were decreased in patients with established CVD compared to those without CVD. Among patients with psoriasis without CVD and statin treatment, GDF-15 levels were negatively associated with vascular inflammation in the ascending aorta and entire aorta, and positively associated with CIMT and CCS. NLR was positively associated with vascular inflammation in the carotid arteries. Our data suggest that circulating GDF-15 levels and NLR might serve as biomarkers of subclinical atherosclerosis in patients with psoriasis.

• Authors: Hannah Kaiser, Xing Wang, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Benjamin D McCauley, Lone Skov, Christine Becker, Peter Riis Hansen
• Journal: Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 21438 (11 02 2021) ISSN: 2045-2322 [Electronic] England
• PMID: 34728734 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021. The Author(s).

Chemical References

• Biomarkers

Topics

• Atherosclerosis (diagnosis, etiology)
• Biomarkers (analysis)
• Cardiovascular Diseases (diagnosis, etiology)
• Carotid Arteries (pathology)
• Female
• Humans
• Lymphocytes (pathology)
• Male
• Middle Aged
• Neutrophils (pathology)
• Psoriasis (complications)
• Risk Factors