Long Non-Coding RNA GAS5 in Age-Related Diseases.

Abstract

Aging refers to a natural process and a universal phenomenon in all cells, tissues, organs, and the whole organism. Long non-coding RNAs (lncRNAs) are non-coding RNAs with a length of 200 nucleotides. LncRNA growth arrest-specific 5 (lncRNA GAS5) is often down-regulated in cancer. The accumulation of lncRNA GAS5 has been found to be able to inhibit cancer growth, invasion, and metastasis while enhancing the sensitivity of cells to chemotherapy drugs. LncRNA GAS5 can be a signaling protein, which is specifically transcribed under different triggering conditions. Subsequently, it is involved in signal transmission in numerous pathways as a signal node. LncRNA GAS5, with a close relationship to multiple miRNAs, was suggested to be involved in the signaling pathway under three action modes (i.e., signal, bait, and guidance). LncRNA GAS5 was found to be involved in different age-related diseases (e.g., rheumatoid arthritis, type 2 diabetes, atherosclerosis, osteoarthritis, osteoporosis, multiple sclerosis, cancer, etc.). This study mainly summarized the regulatory effect exerted by lncRNA GAS5 on age-related diseases.

• Authors: Yaqi Wang, Mengzhen Xue, Fangqi Xia, Leiqi Zhu, Dengke Jia, Yan Gao, Luoying Li, Yue Shi, Yuanyang Li, Silong Chen, Guangfu Xu, Chengfu Yuan
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 29 Issue 16 Pg. 2863-2877 ( 2022) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 34711157 (Publication Type: Journal Article)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• GAS5 long non-coding RNA, human
• MicroRNAs
• RNA, Long Noncoding

Topics

• Aging
• Disease (genetics)
• Humans
• MicroRNAs (genetics)
• RNA, Long Noncoding (genetics)
• Signal Transduction