Therapeutic Impact and Management of Persistent Head and Neck Atopic Dermatitis in Dupilumab-Treated Patients.

Abstract

BACKGROUND:

Localization of atopic dermatitis (AD) in exposed areas such as the hands, head, and neck has been considered as a negative factor impacting on dupilumab response, although a comparison of exposed versus unexposed areas is not currently available.

OBJECTIVES:

The aim of this study is to evaluate the clinical response to dupilumab depending on the presence or persistency of AD skin manifestations in specific body areas.

METHODS:

The study retrospectively collected clinical and demographic data of adult patients affected by moderate to severe AD. Based on the anatomical sites involved, 5 subcohorts of patients were identified.

RESULTS:

A total of 41 patients were included in the study. Disease amelioration was detected during the study period, although baseline head/neck and hand localization was associated with a significantly lower likelihood of achieving an Eczema Area Severity Index (EASI) ≤1. In addition, patients with head/neck persistency showed a significantly lower response when compared to patients without persistency of head/neck AD in terms of both mean EASI and Dermatology Life Quality Index (DLQI) reduction.

CONCLUSION:

AD localization in exposed areas at the baseline and AD persistency at the head/neck may have a negative impact on certain treatment response parameters to dupilumab therapy.

• Authors: Andrea Chiricozzi, Niccolò Gori, Lucia Di Nardo, Flaminia Antonelli, Cristiano Caruso, Giacomo Caldarola, Laura Calabrese, Cristina Guerriero, Clara De Simone, Ketty Peris
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 238 Issue 4 Pg. 717-724 ( 2022) ISSN: 1421-9832 [Electronic] Switzerland
• PMID: 34710866 (Publication Type: Journal Article)
• Copyright: © 2021 S. Karger AG, Basel.

Chemical References

• Antibodies, Monoclonal, Humanized
• dupilumab

Topics

• Adult
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Dermatitis, Atopic (complications, drug therapy)
• Humans
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome