Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome.

Abstract

Good syndrome is a rare condition characterized by the presence of thymoma in combination with adult-onset hypogammaglobulinemia. Immunological features of Good syndrome include various immunodeficiencies accompanied with hypogammaglobulinemia. In patients with thymoma, paraneoplastic syndromes including hypogammaglobulinemia worsen the prognosis. We herein describe a patient with advanced-stage type A thymoma who was effectively treated with chemotherapy and exhibited a parallel decrease in the serum level of soluble interleukin-2 receptor (sIL-2R), which depends on cellular immunity. The present case suggests the efficacy of sIL-2R as a potential prognostic biomarker in a subset of patients with Good syndrome.

• Authors: Haruka Kitano, Fumihiro Yamaguchi, Kenji Atarashi, Mina Hiraiwa, Yo Shiratori, Shota Onozaki, Yusuke Shikama
• Journal: OncoTargets and therapy (Onco Targets Ther) Vol. 14 Pg. 5045-5049 ( 2021) ISSN: 1178-6930 [Print] New Zealand
• PMID: 34675549 (Publication Type: Case Reports)
• Copyright: © 2021 Kitano et al.