A metal-polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy.

Abstract

Photothermal therapy (PTT) achieves substantive therapeutic progress in certain tumor types without exogenous agents but is hampered by the over-activated inflammatory response or tumor recurrence in some cases. Herein, we technically developed the metal-polyphenolic nanosystem with precise NIR-II fluorescence-imaging guidance for combining hafnium (Hf)-sensitized radiotherapy with PTT to regress tumor growth.

• Authors: Jie Li, Wenxi Li, Lisi Xie, Wei Sang, Guohao Wang, Zhan Zhang, Bei Li, Hao Tian, Jie Yan, Ye Tian, Zhenhua Li, Quli Fan, Lin Yu, Yunlu Dai
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 57 Issue 87 Pg. 11473-11476 (Nov 02 2021) ISSN: 1364-548X [Electronic] England
• PMID: 34652356 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Fluorescent Dyes
• Radiopharmaceuticals
• Poloxamer
• Dopamine
• Hafnium

Topics

• Animals
• Antineoplastic Agents (chemistry, therapeutic use)
• Cell Line, Tumor
• Dopamine (analogs & derivatives)
• Female
• Fluorescence
• Fluorescent Dyes (chemistry, therapeutic use)
• Hafnium (chemistry, therapeutic use)
• Mice, Inbred BALB C
• Mice, Nude
• Nanoparticles (chemistry, therapeutic use)
• Neoplasms (diagnostic imaging, drug therapy, radiotherapy)
• Photothermal Therapy
• Poloxamer (chemistry)
• Radiopharmaceuticals (chemistry, therapeutic use)
• Radiotherapy
• Mice