Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy.

Abstract

Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways.

• Authors: Liang Yan, Yanlian Tan, Guo Chen, Jun Fan, Jun Zhang
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 19 (Sep 24 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 34638609 (Publication Type: Journal Article, Review)

Topics

• Animals
• Cellular Reprogramming (immunology)
• Dendritic Cells (immunology, metabolism)
• Disease Progression
• Humans
• Immunotherapy (methods, trends)
• Macrophages (immunology, metabolism)
• Metabolic Networks and Pathways
• Neoplasms (immunology, metabolism, therapy)
• Neoplastic Stem Cells (immunology, metabolism)
• T-Lymphocytes (immunology, metabolism)
• Tumor Microenvironment (immunology)