Abstract | OBJECTIVE: DATA SOURCE: STUDY SELECTION: DATA EXTRACTION: DATA SYNTHESIS: A total of 13 studies with 1,814 invasively ventilated coronavirus disease 2019 patients and 493 noncoronavirus disease 2019 patients were included. A total of 266/1,814 patients (14.7%) had at least one barotrauma event (pooled estimates, 16.1% [95% CI, 11.8-20.4%]). Pneumothorax occurred in 132/1,435 patients (pooled estimates, 10.7%; 95% CI, 6.7-14.7%), whereas pneumomediastinum occurred in 162/1,432 patients (pooled estimates, 11.2%; 95% CI, 8.0-14.3%). Mortality in coronavirus disease 2019 patients who developed barotrauma was 111/198 patients (pooled estimates, 61.6%; 95% CI, 50.2-73.0%). In noncoronavirus disease 2019 acute respiratory distress syndrome patients, barotrauma occurred in 31/493 patients (6.3%; pooled estimates, 5.7%; 95% CI, -2.1% to 13.5%). CONCLUSIONS:
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Authors | Alessandro Belletti, Gabriele Todaro, Gabriele Valsecchi, Rosario Losiggio, Diego Palumbo, Giovanni Landoni, Alberto Zangrillo |
Journal | Critical care medicine
(Crit Care Med)
Vol. 50
Issue 3
Pg. 491-500
(03 01 2022)
ISSN: 1530-0293 [Electronic] United States |
PMID | 34637421
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved. |
Topics |
- Barotrauma
(etiology, mortality)
- COVID-19
(mortality, therapy)
- Humans
- Mediastinal Emphysema
(etiology, mortality)
- Pneumothorax
(etiology, mortality)
- Respiration, Artificial
(adverse effects)
- SARS-CoV-2
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