Abstract | INTRODUCTION: MATERIAL AND METHODS: An immunohistochemistry (IHC) panel of Olig2, EMA, and CD99 was performed on 18 central neurocytomas, 46 ependymomas, and 28 oligodendrogliomas. A quantitative labelling index of stained tumor cells was assessed using a scoring system, and its diagnostic predictability was evaluated with multinomial logistic regression. RESULTS: Significant differences in IHC expression patterns were observed between all tumor groups (p < 0.001). The labeling indices of the histochemical expression of Olig2, EMA, and CD99 were related to diagnostic predictability. Olig2 was unlikely to differentiate ependymoma from central neurocytoma (p = 0.154), while EMA and CD99 were significant in diagnosing these two tumors (p < 0.05). Olig2 was a specific marker of oligodendroglioma, differentiating it from ependymoma and central neurocytoma (p 0.05), but CD99 significantly differentiated ependymoma from oligodendroglioma (p = 0.022). These labelling indices were used to re-assess the diagnostic accuracy, regardless of tumor location and histology, and yielded significantly different tumor diagnoses. CONCLUSIONS:
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Authors | Maher Kurdi, Charles Eberhart |
Journal | Folia neuropathologica
(Folia Neuropathol)
Vol. 59
Issue 3
Pg. 284-290
( 2021)
ISSN: 1509-572X [Electronic] Poland |
PMID | 34628794
(Publication Type: Journal Article)
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Chemical References |
- 12E7 Antigen
- Biomarkers, Tumor
- CD99 protein, human
- Mucin-1
- OLIG2 protein, human
- Oligodendrocyte Transcription Factor 2
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Topics |
- 12E7 Antigen
- Biomarkers, Tumor
- Brain Neoplasms
(diagnosis)
- Ependymoma
(diagnosis)
- Humans
- Mucin-1
- Neurocytoma
- Oligodendrocyte Transcription Factor 2
- Oligodendroglia
- Oligodendroglioma
(diagnosis)
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