Abstract | BACKGROUND: AIMS/OBJECTIVES: The aim of this study was to provide the highest level of evidence possible by performing a systematic review and meta-analysis of the literature. MATERIAL AND METHODS: RESULTS: A total of 522 abstracts were studied, data analyzed from 14 studies, on a total of 697 patients. When the data werepooled, the overall risk of further recurrence was 21%. In studies where surgery alone was undertaken this increased to 26% and decreased to 10% in those receiving adjuvant radiotherapy (p = .000). There were 21 recurrences in 159 patients in the radiotherapy group, and 151 recurrences out of 538 patients in the surgery group (p < .0001). CONCLUSIONS: SIGNIFICANCE: This study is the highest level of evidence currently available in guiding management of recurrent pleomorphic adenoma.
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Authors | Justin M Hintze, Fergal O'Duffy, Ailbhe White-Gibson, Paul O'Neill, John Kinsella, Conrad Timon, Paul Lennon |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 141
Issue 10
Pg. 971-976
(Oct 2021)
ISSN: 1651-2251 [Electronic] England |
PMID | 34622733
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Topics |
- Adenoma, Pleomorphic
(therapy)
- Humans
- Neoplasm Recurrence, Local
(therapy)
- Parotid Neoplasms
(therapy)
- Radiotherapy, Adjuvant
- Secondary Prevention
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